An Artificial Heme Enzyme for Cyclopropanation Reactions
نویسندگان
چکیده
منابع مشابه
Stereoselective cyclopropanation reactions.
Organic chemists have always been fascinated by the cyclopropane subunit.1 The smallest cycloalkane is found as a basic structural element in a wide range of naturally occurring compounds.2 Moreover, many cyclopropane-containing unnatural products have been prepared to test the bonding features of this class of highly strained cycloalkanes3 and to study enzyme mechanism or inhibition.4 Cyclopro...
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Myoglobin has recently emerged as a promising biocatalyst for catalyzing carbene-mediated cyclopropanation, a synthetically valuable transformation not found in nature. Having naturally evolved for binding dioxygen, the carbene transferase activity of this metalloprotein is severely inhibited by it, imposing the need for strictly anaerobic conditions to conduct these reactions. In this report, ...
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Copper-bis(oxazoline) complexes have been immobilised in the hydrophobic domain of a polymersome membrane to perform asymmetric cyclopropanation reactions in aqueous media with enhanced conversions and enantioselectivities.
متن کاملEngineering a dirhodium artificial metalloenzyme for selective olefin cyclopropanation
Artificial metalloenzymes (ArMs) formed by incorporating synthetic metal catalysts into protein scaffolds have the potential to impart to chemical reactions selectivity that would be difficult to achieve using metal catalysts alone. In this work, we covalently link an alkyne-substituted dirhodium catalyst to a prolyl oligopeptidase containing a genetically encoded L-4-azidophenylalanine residue...
متن کاملAn intramolecular organocatalytic cyclopropanation reaction.
Catalytic processes that form functionalized cyclic molecules represent a key transformation for synthetic organic chemistry. Recently, a number of organocatalytic processes have emerged that often provide excellent levels of both enantioand diastereocontrol for the synthesis of cyclic molecules. Our recent studies have identified the utility of ammonium ylides for carbon–carbon bond formation....
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2018
ISSN: 1433-7851
DOI: 10.1002/anie.201802946